Characterization of Recombinant Monoclonal Antibody Charge Variants Using OFFGEL Fractionation, Weak Anion Exchange Chromatography, and Mass Spectrometry-Reference-Cited by-同舟云学术

Characterization of Recombinant Monoclonal Antibody Charge Variants Using OFFGEL Fractionation, Weak Anion Exchange Chromatography, and Mass Spectrometry

Published:2015-05-28 Issue:12 Volume:87 Page:6204-6211
ISSN:0003-2700
Container-title:Analytical Chemistry
language:en
Short-container-title:Anal. Chem.

Author:

Neill Alyssa¹,Nowak Christine¹,Patel Rekha¹,Ponniah Gomathinayagam¹,Gonzalez Nidia¹,Miano Dino¹,Liu Hongcheng¹

Affiliation:

1. Product Characterization, Alexion Pharmaceuticals Inc, 352 Knotter Drive, Cheshire, Connecticut 06410, United States

Publisher

American Chemical Society (ACS)

Subject

Analytical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.analchem.5b01452

Reference36 articles.

1. Heterogeneity of Monoclonal Antibodies

2. Heterogeneity of Monoclonal Antibodies Revealed by Charge-Sensitive Methods

3. Chromatographic analysis of the acidic and basic species of recombinant monoclonal antibodies

4. Characterization by liquid chromatography combined with mass spectrometry of monoclonal anti-IGF-1 receptor antibodies produced in CHO and NS0 cells

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