Characterization of Recombinant Monoclonal Antibody Charge Variants Using OFFGEL Fractionation, Weak Anion Exchange Chromatography, and Mass Spectrometry
Author:
Affiliation:
1. Product Characterization, Alexion Pharmaceuticals Inc, 352 Knotter Drive, Cheshire, Connecticut 06410, United States
Publisher
American Chemical Society (ACS)
Subject
Analytical Chemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.analchem.5b01452
Reference36 articles.
1. Heterogeneity of Monoclonal Antibodies
2. Heterogeneity of Monoclonal Antibodies Revealed by Charge-Sensitive Methods
3. Chromatographic analysis of the acidic and basic species of recombinant monoclonal antibodies
4. Characterization by liquid chromatography combined with mass spectrometry of monoclonal anti-IGF-1 receptor antibodies produced in CHO and NS0 cells
5. Biosimilar, Biobetter, and Next Generation Antibody Characterization by Mass Spectrometry
Cited by 43 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. An Online Two-Dimensional Approach to Characterizing the Charge-Based Heterogeneity of Recombinant Monoclonal Antibodies Using a 2D-CEX–AEX–MS Workflow;Journal of the American Society for Mass Spectrometry;2023-11-23
2. Small conformational changes in IgG1 detected as acidic charge variants by cation exchange chromatography;Analytical Biochemistry;2023-11
3. Bioprocess Challenges in Purification of Therapeutic Protein Charge Variants;Biotechnology and Bioprocess Engineering;2023-05-29
4. In-Depth Characterization of Acidic Variants Induced by Metal-Catalyzed Oxidation in a Recombinant Monoclonal Antibody;Analytical Chemistry;2023-03-27
5. Risk-Based Control Strategies of Recombinant Monoclonal Antibody Charge Variants;Antibodies;2022-11-20
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3