By Increasing the Affinity of Heparin for Fibrin, Zn2+ Promotes the Formation of a Ternary Heparin–Thrombin–Fibrin Complex That Protects Thrombin from Inhibition by Antithrombin-Reference-Cited by-同舟云学术

By Increasing the Affinity of Heparin for Fibrin, Zn2+ Promotes the Formation of a Ternary Heparin–Thrombin–Fibrin Complex That Protects Thrombin from Inhibition by Antithrombin

Published:2012-09-28 Issue:40 Volume:51 Page:7964-7973
ISSN:0006-2960
Container-title:Biochemistry
language:en
Short-container-title:Biochemistry

Author:

Chan Howard H.¹,Leslie Beverly A.¹,Stafford Alan R.¹,Roberts Robin S.¹,Al-Aswad Nadine N.¹,Fredenburgh James C.¹,Weitz Jeffrey I.¹

Affiliation:

1. Departments of Medicine, ‡Biochemistry and Biomedical Sciences, and §Clinical Epidemiology & Biostatistics, McMaster University, and the Thrombosis and Atherosclerosis Research Institute, Hamilton, Ontario, Canada

Publisher

American Chemical Society (ACS)

Subject

Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/bi301046b

Reference64 articles.

1. A dual thrombin receptor system for platelet activation

2. Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation

3. Thrombin Formation

4. Human plasma fibrinogen heterogeneity: evidence for an extended carboxyl-terminal sequence in a normal gamma chain variant (gamma').

5. Identification and Characterization of the Thrombin Binding Sites on Fibrin

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