Passive Lipoidal Diffusion and Carrier-Mediated Cell Uptake Are Both Important Mechanisms of Membrane Permeation in Drug Disposition

Author:

Smith Dennis1,Artursson Per2,Avdeef Alex3,Di Li4,Ecker Gerhard F.5,Faller Bernard6,Houston J. Brian7,Kansy Manfred8,Kerns Edward H.9,Krämer Stefanie D.10,Lennernäs Hans2,van de Waterbeemd Han11,Sugano Kiyohiko12,Testa Bernard13

Affiliation:

1. 4 The Maltings, Walmer, Kent, CT14 7AR, U.K.

2. Department of Pharmacy, Biomedical Centre, Uppsala University, S-752 63 Uppsala, Box 580, Sweden

3. 1732 First Avenue, #102, New York, New York 10128, United States

4. Pharmacokinetics, Dynamics and Metabolism, Pfizer Inc., Groton, Connecticut 06340, United States

5. Department of Medicinal Chemistry, University of Vienna, Althanstrasse, 141090 Wien, Austria

6. Novartis Institutes for Biomedical Research, WSJ-350.3.04, CH-4002 Basel, Switzerland

7. School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Oxford Road, Manchester, M13 9PT, U.K.

8. The Non-Clinical Safety Department, F. Hoffmann-La Roche, CH-4070 Basel, Switzerland

9. National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States

10. Institute of Pharmaceutical Sciences, ETH, Zürich, Switzerland

11. 14 Rue de la Rasclose, 66690 Saint André, France

12. Research Formulation, Sandwich Laboratories, Ramsgate Road, Sandwich, Kent CT13 9NJ, U.K.

13. Department of Pharmacy, University Hospital Lausanne, CH-1011 Lausanne, Switzerland

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

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