Identification of Novel Cyclooxygenase-2 Selective Inhibitors Using Pharmacophore Models
Author:
Affiliation:
1. R&D Department, Laboratorios Menarini S.A., Alfonso XII 587, 08918 Badalona, Spain, and Departamento de Química Orgánica, Facultad de Farmacia, Universidad de Granada, Campus de la Cartuja s/n, 18071 Granada, Spain
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/jm010458r
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1. Inhibition of Prostaglandin Synthetase in Brain explains the Anti-pyretic Activity of Paracetamol (4-Acetamidophenol)
2. Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing.
3. Synthesis and Biological Evaluation of the 1,5-Diarylpyrazole Class of Cyclooxygenase-2 Inhibitors: Identification of 4-[5-(4-Methylphenyl)-3- (trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide (SC-58635, Celecoxib)
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