Discovery of a Potent, Selective, and Orally Bioavailable Pyridinyl-Pyrimidine Phthalazine Aurora Kinase Inhibitor
Author:
Affiliation:
1. Medicinal Chemistry
2. Pharmaceutics
3. Pharmacokinetics and Drug Metabolism
4. Molecular Structure
5. Oncology Research
6. Molecular Pharmacology
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/jm100394y
Reference37 articles.
1. Roles of Aurora Kinases in Mitosis and Tumorigenesis
2. Aurora-kinase inhibitors as anticancer agents
3. The cellular geography of Aurora kinases
4. Aurora kinases in spindle assembly and chromosome segregation
5. Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores
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