1. School of Pharmacy, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan, The Kitasato Institute, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8642, Japan, Department of Medicinal Chemistry, Yokohama College of Pharmacy, 601 Matanocyo, Hodogayaku, Yokohama-shi, Kanagawa 245-0066, Japan, and Kitasato Institute for Life Sciences and Graduate School of Infection Control Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641 Japan