1. Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan, Kochi Kita Highschool, 160 Higashiishidate, Kochi 780-8039, Japan, and The Kitasato Institute, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8642, Japan