Quantitation of Parent Drug and Its Unstable Metabolites by in Situ Coulometric Oxidation and Liquid Chromatography−Tandem Mass Spectrometry-Reference-Cited by-同舟云学术

Quantitation of Parent Drug and Its Unstable Metabolites by in Situ Coulometric Oxidation and Liquid Chromatography−Tandem Mass Spectrometry

Published:2010-11-24 Issue:24 Volume:82 Page:10251-10257
ISSN:0003-2700
Container-title:Analytical Chemistry
language:en
Short-container-title:Anal. Chem.

Author:

Tong Wei¹,Chowdhury Swapan K.¹,Su Ai-Duen¹,Alton Kevin B.¹

Affiliation:

1. Drug Metabolism and Pharmacokinetics, Merck Research Laboratories, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States

Publisher

American Chemical Society (ACS)

Subject

Analytical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/ac102538s

Reference34 articles.

1. U.S. Food and Drug Administration. Guidance for Industry: Safety Testing of Drug Metabolites, http://www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/ucm079266.pdf, 2008

2. International Conference on Harmonisation. Non-clinical safety studies for the conduct of human trials for pharmaceuticals. ICH guidance M3(R2),http://www.emea.europa.eu/pdfs/human/ich/028695en.pdf, 2009.

3. Electrospray interface for liquid chromatographs and mass spectrometers

4. Liquid chromatography/mass spectrometry

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