Pyrrolo[1,2-b][1,2,5]benzothiadiazepines (PBTDs): A New Class of Agents with High Apoptotic Activity in Chronic Myelogenous Leukemia K562 Cells and in Cells from Patients at Onset and Who Were Imatinib-Resistant-Reference-Cited by-同舟云学术

Pyrrolo[1,2-b][1,2,5]benzothiadiazepines (PBTDs): A New Class of Agents with High Apoptotic Activity in Chronic Myelogenous Leukemia K562 Cells and in Cells from Patients at Onset and Who Were Imatinib-Resistant

Published:2006-08-09 Issue:19 Volume:49 Page:5840-5844
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Silvestri Romano¹,Marfè Gabriella¹,Artico Marino¹,La Regina Giuseppe¹,Lavecchia Antonio¹,Novellino Ettore¹,Morgante Manuela¹,Di Stefano Carla¹,Catalano Gianfranco¹,Filomeni Giuseppe¹,Abruzzese Elisabetta¹,Ciriolo Maria Rosa¹,Russo Matteo Antonio¹,Amadori Sergio¹,Cirilli Roberto¹,La Torre Francesco¹,Sinibaldi Salimei Paola¹

Affiliation:

1. Istituto PasteurFondazione Cenci Bolognetti, Dipartimento di Studi Farmaceutici, Università “La Sapienza”, Piazzale Aldo Moro 5, I-00185 Roma, Italy, Dipartimento di Medicina Sperimentale e Scienze Biochimiche, Università “Tor Vergata”, Via Montpellier 1, I-00133 Roma, Italy, Dipartimento di Chimica Farmaceutica e Tossicologica, Università di Napoli “Federico II”, Via Domenico Montesano 49, I-80131 Napoli, Italy, Dipartimento di Medicina Sperimentale e Patologia, Università “La Sapienza”, Viale Regina...

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm0602716

Reference23 articles.

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3. Molecular pathogenesis of chronic myeloid leukemia: implications for new therapeutic strategies

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5. The leukaemic oncoproteins Bcr-Abl and Tel-Abl (ETV6/Abl) have altered substrate preferences and activate similar intracellular signalling pathways

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