NMR-Derived Models of Amidopyrine and Its Metabolites in Complexes with Rabbit Cytochrome P450 2B4 Reveal a Structural Mechanism of Sequential N-Dealkylation-Reference-Cited by-同舟云学术

NMR-Derived Models of Amidopyrine and Its Metabolites in Complexes with Rabbit Cytochrome P450 2B4 Reveal a Structural Mechanism of Sequential N-Dealkylation

Published:2011-03-04 Issue:12 Volume:50 Page:2123-2134
ISSN:0006-2960
Container-title:Biochemistry
language:en
Short-container-title:Biochemistry

Author:

Roberts Arthur G.¹,Sjögren Sara E. A.²,Fomina Nadezda¹,Vu Kathy T.³,Almutairi Adah¹,Halpert James R.¹

Affiliation:

1. The Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Drive, #0703, La Jolla, California 92093-0703, United States

2. Lund University, BMC F12, S-221 84 Lund, Sweden

3. University of Gothenburg, Sahlgrenska Academy, Box 400, 405 30 Gothenburg, Sweden

Publisher

American Chemical Society (ACS)

Subject

Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/bi101797v

Reference79 articles.

1. Structure–function analysis of cytochromes P450 2B

2. Evidence for a 1-Electron Oxidation Mechanism in N-Dealkylation of N,N-Dialkylanilines by Cytochrome P450 2B1

3. Evidence for a hydrogen abstraction mechanism in P450-catalyzed N-dealkylations

4. Spin state control of cytochrome P-450 reduction and catalytic activity in a reconstituted P-450 LM2 system as induced by a series of benzphetamine analogues

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