Process Development and Scale-Up of AZD7545, a PDK Inhibitor-Reference-Cited by-同舟云学术

Process Development and Scale-Up of AZD7545, a PDK Inhibitor

Published:2012-03-06 Issue:3 Volume:16 Page:447-460
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Patel Bharti¹²,Firkin Catherine R.¹²,Snape Evan W.¹²,Jenkin Shelley L.¹²,Brown David¹²,Chaffey Julian G. K.¹²,Hopes Philip A.¹²,Reens Carl D.¹²,Butters Mike¹²,Moseley Jonathan D.¹²

Affiliation:

1. Process Research and Development, Avlon Works, AstraZeneca, Severn Road, Hallen, Bristol BS10 7ZE, United Kingdom

2. Development Manufacture, R&DCharnwood, AstraZeneca, Bakewell Road, Loughborough LE11 5RH, United Kingdom

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/op2003419

Reference20 articles.

1. Butlin, R. J., Nowak, T., Burrows, J. N., and Block, M. H.PCT Int. Appl. WO 1999/9962506 A1, 1999.

2. PDH kinase inhibitors: a novel therapy for Type II diabetes?

3. AZD7545 is a selective inhibitor of pyruvate dehydrogenase kinase 2

4. Kepner-Tregoe Decision Analysis as a Tool to Aid Route Selection. Part 1

5. Kepner-Tregoe Decision Analysis as a Tool To Aid Route Selection. Part 2. Application to AZD7545, a PDK Inhibitor

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