Mechanism of Action of the Cell-Division Inhibitor PC190723: Modulation of FtsZ Assembly Cooperativity
Author:
Affiliation:
1. Screening and Protein Sciences, Merck Research Laboratories, West Point, Pennsylvania 19486, United States
2. Global Structural Chemistry, Merck Research Laboratories, West Point, Pennsylvania 19486, United States
Publisher
American Chemical Society (ACS)
Subject
Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis
Link
https://pubs.acs.org/doi/pdf/10.1021/ja303564a
Reference27 articles.
1. FtsZ in Bacterial Cytokinesis: Cytoskeleton and Force Generator All in One
2. Bacterial cell division: assembly, maintenance and disassembly of the Z ring
3. Rate-Limiting Guanosine 5‘-Triphosphate Hydrolysis during Nucleotide Turnover by FtsZ, a Prokaryotic Tubulin Homologue Involved in Bacterial Cell Division
4. FtsZ inhibition: A promising approach for antistaphylococcal therapy
5. Cell-division inhibitors: new insights for future antibiotics
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