Design and Synthesis of 5-Aryl-pyridone-carboxamides as Inhibitors of Anaplastic Lymphoma Kinase-Reference-Cited by-同舟云学术

Design and Synthesis of 5-Aryl-pyridone-carboxamides as Inhibitors of Anaplastic Lymphoma Kinase

Published:2006-01-19 Issue:3 Volume:49 Page:1006-1015
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Li Rongshi¹,Xue Liquan¹,Zhu Tong¹,Jiang Qin¹,Cui Xiaoli¹,Yan Zheng¹,McGee Danny¹,Wang Jian¹,Gantla Vidyasagar Reddy¹,Pickens Jason C.¹,McGrath Doug¹,Chucholowski Alexander¹,Morris Stephan W.¹,Webb Thomas R.¹

Affiliation:

1. ChemBridge Research Laboratories and ChemBridge Corporation, 16981 Via Tazon, Suites K and G, San Diego, California 92127, and Departments of Pathology and Hematology-Oncology, St. Jude Children's Research Hospital, 332 N. Lauderdale Street, Memphis, Tennessee 38105

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm050824x

Reference58 articles.

1. Fusion of a Kinase Gene, ALK , to a Nucleolar Protein Gene, NPM , in Non-Hodgkin's Lymphoma

2. Molecular characterization of ALK, a receptor tyrosine kinase expressed specifically in the nervous system

3. ALK, the chromosome 2 gene locus altered by the t(2;5) in non-Hodgkin's lymphoma, encodes a novel neural receptor tyrosine kinase that is highly related to leukocyte tyrosine kinase (LTK)

4. Anaplastic lymphoma kinase proteins in growth control and cancer

5. The ltk receptor tyrosine kinase is expressed in pre-B lymphocytes and cerebral neurons and uses a non-AUG translational initiator.

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