Development of Novel Aminoglycoside (NB54) with Reduced Toxicity and Enhanced Suppression of Disease-Causing Premature Stop Mutations-Reference-Cited by-同舟云学术

Development of Novel Aminoglycoside (NB54) with Reduced Toxicity and Enhanced Suppression of Disease-Causing Premature Stop Mutations

Published:2009-03-23 Issue:9 Volume:52 Page:2836-2845
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Nudelman Igor¹,Rebibo-Sabbah Annie¹,Cherniavsky Marina¹,Belakhov Valery¹,Hainrichson Mariana¹,Chen Fuquan¹,Schacht Jochen¹,Pilch Daniel S.¹,Ben-Yosef Tamar¹,Baasov Timor¹

Affiliation:

1. The Edith and Joseph Fischer Enzyme Inhibitors Laboratory, Schulich Faculty of Chemistry, Technion—Israel Institute of Technology, Haifa 32000, Israel, Department of Genetics and The Rappaport Family Institute for Research in the Medical Sciences, Faculty of Medicine, Technion—Israel Institute of Technology, Haifa 31096, Israel, Kresge Hearing Research Institute, University of Michigan, Ann Arbor, Michigan, Department of Pharmacology, University of Medicine and Density of New Jersey, Robert Wood Johnson...

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm801640k

Reference44 articles.

1. Pharmacological Suppression of Premature Stop Mutations that Cause Genetic Diseases

2. A meta-analysis of nonsense mutations causing human genetic disease

3. Suppression of a nonsense mutation in mammalian cellsin vivoby the aminoglycoside anthiotics G–418 and paromomycin

4. Correction of genetic disease by making sense from nonsense

5. Aminoglycoside antibiotics mediate context-dependent suppression of termination codons in a mammalian translation system

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