Structure-Based Discovery of BM-957 as a Potent Small-Molecule Inhibitor of Bcl-2 and Bcl-xL Capable of Achieving Complete Tumor Regression-Reference-Cited by-同舟云学术

Structure-Based Discovery of BM-957 as a Potent Small-Molecule Inhibitor of Bcl-2 and Bcl-xL Capable of Achieving Complete Tumor Regression

Published:2012-10-02 Issue:19 Volume:55 Page:8502-8514
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Chen Jianfang¹,Zhou Haibin¹,Aguilar Angelo¹,Liu Liu¹,Bai Longchuan¹,McEachern Donna¹,Yang Chao-Yie¹,Meagher Jennifer L.¹,Stuckey Jeanne A.¹,Wang Shaomeng¹

Affiliation:

1. Comprehensive Cancer Center and Departments of Internal Medicine, Pharmacology and Medicinal Chemistry and ‡Life Sciences Institute, University of Michigan, 1500 East Medical Center Drive, Ann Arbor, Michigan 48109-0934, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm3010306

Reference40 articles.

1. Apoptosis in cancer

2. Apoptosis-based therapies

3. The Hallmarks of Cancer

4. From bench to clinic with apoptosis-based therapeutic agents

5. Bcl-2-regulated apoptosis: mechanism and therapeutic potential

Cited by 52 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Development and crystal structures of a potent second-generation dual degrader of BCL-2 and BCL-xL;Nature Communications;2024-03-29

2. B‐cell lymphoma‐2 family proteins in the crosshairs: Small molecule inhibitors and activators for cancer therapy;Medicinal Research Reviews;2023-11-20

3. Benzimidazol-2-ylidene ruthenium complexes for C-N bond formation through alcohol dehydrogenation;Turkish Journal of Chemistry;2023-10-31

4. N-Methyl-N-arylformamides: Synthesis and Interaction of with Carbonic Anhydrase (PDB: 3FW3) and Nuclease (PDB: 6O70) Enzymes via In Silico Molecular Docking;Russian Journal of General Chemistry;2023-01

5. Cascade reaction of 3-formylchromones: Highly selective synthesis of 4-oxo-3-(1H-pyrrol-3-yl)-4H-chromenes;Green Synthesis and Catalysis;2022-10