An Efficient and Scalable Synthesis of the Spirocyclic Glycine Transporter Inhibitor GSK2137305-Reference-Cited by-同舟云学术

An Efficient and Scalable Synthesis of the Spirocyclic Glycine Transporter Inhibitor GSK2137305

Published:2010-11-10 Issue:1 Volume:15 Page:44-48
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Graham Jonathan P.¹,Langlade Nathalie¹,Northall John M.¹,Roberts Alastair J.¹,Whitehead Andrew J.¹

Affiliation:

1. Chemical Development, GlaxoSmithKline R&D, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, U.K.

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/op100210s

Reference21 articles.

1. aBlunt, R., Cooper, D. G., Porter, R. A., and Wyman, P. A.Patent Application WO 2009/034061 A1, 2009.

2. bFor a recent review on inhibitors of GlyT1 for the treatment of schizophrenia, see:

3. The chemistry as detailed in ref1awas adapted by Simone Spada and Roberto Profeta at GSK Verona for the preparation of the first 50 g of GSK2137305.

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