Discovery of Small Molecule RIP1 Kinase Inhibitors for the Treatment of Pathologies Associated with Necroptosis-Reference-Cited by-同舟云学术

Discovery of Small Molecule RIP1 Kinase Inhibitors for the Treatment of Pathologies Associated with Necroptosis

Published:2013-11-06 Issue:12 Volume:4 Page:1238-1243
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Harris Philip A.,Bandyopadhyay Deepak,Berger Scott B.,Campobasso Nino,Capriotti Carol A.,Cox Julie A.,Dare Lauren,Finger Joshua N.,Hoffman Sandra J.,Kahler Kirsten M.¹,Lehr Ruth,Lich John D.,Nagilla Rakesh,Nolte Robert T.¹,Ouellette Michael T.,Pao Christina S.,Schaeffer Michelle C.,Smallwood Angela,Sun Helen H.,Swift Barbara A.,Totoritis Rachel D.,Ward Paris,Marquis Robert W.,Bertin John,Gough Peter J.

Affiliation:

1. Platform Technology & Science, GlaxoSmithKline, Research Triangle Park, North Carolina 27709, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/ml400382p

Reference23 articles.

1. Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome

2. DAMPs, PAMPs and alarmins: all we need to know about danger

3. Necroptosis Turns TNF Lethal