Discovery of S-[5-Amino-1-(4-fluorophenyl)-1H-pyrazol-4-yl]-[3-(2,3-dihydroxypropoxy)phenyl]methanone (RO3201195), an Orally Bioavailable and Highly Selective Inhibitor of p38 Map Kinase-Reference-Cited by-同舟云学术

Discovery of S-[5-Amino-1-(4-fluorophenyl)-1H-pyrazol-4-yl]-[3-(2,3-dihydroxypropoxy)phenyl]methanone (RO3201195), an Orally Bioavailable and Highly Selective Inhibitor of p38 Map Kinase

Published:2006-02-09 Issue:5 Volume:49 Page:1562-1575
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Goldstein David M.¹,Alfredson Tom¹,Bertrand Jay¹,Browner Michelle F.¹,Clifford Ken¹,Dalrymple Stacie A.¹,Dunn James¹,Freire-Moar Jose¹,Harris Seth¹,Labadie Sharada S.¹,La Fargue JoAnn¹,Lapierre Jean Marc¹,Larrabee Susan¹,Li Fujun¹,Papp Eva¹,McWeeney Daniel¹,Ramesha Chakk¹,Roberts Rick¹,Rotstein David¹,San Pablo Bong¹,Sjogren Eric B.¹,So On-Yee¹,Talamas Francisco X.¹,Tao Will¹,Trejo Alejandra¹,Villasenor Armando¹,Welch Mary¹,Welch Teresa¹,Weller Paul¹,Whiteley Phyllis E.¹,Young Kelly¹,Zipfel Sheila¹

Affiliation:

1. Roche Palo Alto LLC, 3431 Hillview Avenue, R6-123, Palo Alto, California 94304, Pharmacia Italy, Pfizer Group, Milan 20014, Italy, Celera Genomics, 180 Kimball Way, South San Francisco, California 94080, Forest Research Institute, Harborside Financial Center, Jersey City, New Jersey 07311, Arqule, Inc., 19 Presidential Way Woburn, Massachusetts 01801, and Perlegen Sciences, Inc., 2021 Stierlin Court, Mountain View, California 94043

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm050736c

Reference31 articles.

1. Inflammatory cytokines: interleukin-1 and tumor necrosis factor as effector molecules in autoimmune diseases

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