32-Indolyl Ether Derivatives of Ascomycin: Three-Dimensional Structures of Complexes with FK506-Binding Protein-Reference-Cited by-同舟云学术

32-Indolyl Ether Derivatives of Ascomycin: Three-Dimensional Structures of Complexes with FK506-Binding Protein

Published:1999-07-01 Issue:15 Volume:42 Page:2798-2804
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Becker Joseph W.¹,Rotonda Jennifer¹,Cryan John G.¹,Martin Mary¹,Parsons William H.¹,Sinclair Peter J.¹,Wiederrecht Greg¹,Wong Frederick¹

Affiliation:

1. Departments of Endocrinology and Chemical Biology, Medicinal Chemistry, and Immunology Research, Merck Research Laboratories, P.O. Box 2000, Rahway, New Jersey 07065-0900

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm9806042

Reference30 articles.

1. FK-506- and CsA-sensitive activation of the interleukin-2 promoter by calcineurin

2. X-ray structure of calcineurin inhibited by the immunophilin-immunosuppressant FKBP12-FK506 complex

3. Crystal structures of human calcineurin and the human FKBP12–FK506–calcineurin complex

4. Charged surface residues of FKBP12 participate in formation of the FKBP12-FK506-calcineurin complex.

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