1. Department of Biomedical and Pharmaceutical Sciences, University of Rhode Island, Kingston, Rhode Island 02881, Department of Pharmaceutical Sciences, University of Connecticut, Storrs, Connecticut 06269, Department of Pharmacology and Toxicology, University of Arizona, Tucson, Arizona 85721, Department of Pathology, VU Medical Center, Vrije Universiteit, Amsterdam, The Netherlands, and Department of Pathology & Laboratory Medicine, Brown University, Providence, Rhode Island 02903