Antimalarial versus Cytotoxic Properties of Dual Drugs Derived From 4-Aminoquinolines and Mannich Bases: Interaction with DNA

Author:

Wenzel Nicole I.1,Chavain Natascha2,Wang Yulin3,Friebolin Wolfgang1,Maes Louis4,Pradines Bruno5,Lanzer Michael3,Yardley Vanessa6,Brun Reto7,Herold-Mende Christel8,Biot Christophe2,Tóth Katalin9,Davioud-Charvet Elisabeth110

Affiliation:

1. Biochemie-Zentrum der Universität Heidelberg, Im Neuenheimer Feld 504, D-69120 Heidelberg, Germany

2. Université de Lille 1, Unité de Catalyse et de Chimie du Solide-UMR CNRS 8181, ENSCL, Bâtiment C7, USTL, B.P. 90108, F-59652 Villeneuve d’Ascq Cedex, France

3. University of Heidelberg, Department of Infectiology, D-69120 Heidelberg, Germany

4. University of Antwerp, Groenenborgerlaan 171, B-2020 Antwerpen, Belgium

5. Institut de Recherche Biomédicale des Armées antenne de Marseille, Unité de Recherche en Biologie et Epidémiologie Parasitaires, UMR 6236, Allée du Médecin-colonel Jamot, Le Pharo, BP 60109, F-13262 Marseille Cedex, France

6. Department of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, Keppel Street, London WC1E 7HT, U.K.

7. Swiss Tropical and Public Health Institute, Medical Parasitology and Infection Biology, CH-4002 Basel, Switzerland and University of Basel, Basel, Switzerland

8. Department of Neurosurgery, University of Heidelberg, D-69120 Heidelberg, Germany

9. Division Biophysics of Macromolecules, German Cancer Research Center, Im Neuenheimer Feld 580, D-69120 Heidelberg, Germany

10. European School of Chemistry, Polymers and Materials (ECPM), Université de Strasbourg, 25 rue Becquerel, F-67087 Strasbourg Cedex 2, France

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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