Synthesis and Biological Evaluation of a New Series of 1,2,4-Triazolo[1,5-a]-1,3,5-triazines as Human A2A Adenosine Receptor Antagonists with Improved Water Solubility-Reference-Cited by-同舟云学术

Synthesis and Biological Evaluation of a New Series of 1,2,4-Triazolo[1,5-a]-1,3,5-triazines as Human A2A Adenosine Receptor Antagonists with Improved Water Solubility

Published:2011-01-07 Issue:3 Volume:54 Page:877-889
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Federico Stephanie¹,Paoletta Silvia²,Cheong Siew Lee³,Pastorin Giorgia³,Cacciari Barbara⁴,Stragliotto Stefano²,Klotz Karl Norbert⁵,Siegel Jeffrey⁶,Gao Zhan-Guo⁶,Jacobson Kenneth A.⁶,Moro Stefano²,Spalluto Giampiero¹

Affiliation:

1. Dipartimento di Scienze Farmaceutiche, Università di Trieste, Piazzale Europa 1, I-34127 Trieste, Italy

2. Molecular Modeling Section (MMS), Dipartimento di Scienze Farmaceutiche, Università di Padova, via Marzolo 5, I-35131 Padova, Italy

3. Department of Pharmacy, National University of Singapore, 3 Science Drive 2, Singapore 117543

4. Dipartimento di Scienze Farmaceutiche, Università degli Studi di Ferrara, via Fossato di Mortara 17-19, I-44100 Ferrara, Italy

5. Institut für Pharmakologie, Universität of Würzburg, D-97078 Würzburg, Germany

6. Molecular Recognition Section (MRS), Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm101349u

Reference54 articles.

1. Structure and function of adenosine receptors and their genes

2. Cellular Mechanisms in Ischemic Preconditioning: The Role of Adenosine and Protein Kinase C a

3. Canine Mast Cell Adenosine Receptors: Cloning and Expression of the A3 Receptor and Evidence that Degranulation Is Mediated by the A2B Receptor

4. Adenosine receptor ligands: differences with acute versus chronic treatment

5. Chapter 11 Adenosine and Neuroprotection

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