Charge and Substituent Effects on Affinity and Metabolism of Benzbromarone-Based CYP2C19 Inhibitors-Reference-Cited by-同舟云学术

Charge and Substituent Effects on Affinity and Metabolism of Benzbromarone-Based CYP2C19 Inhibitors

Published:2004-11-26 Issue:27 Volume:47 Page:6768-6776
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Locuson Charles W.¹,Suzuki Hisashi¹,Rettie Allan E.¹,Jones Jeffrey P.¹

Affiliation:

1. School of Molecular Biosciences, Washington State University, Pullman, Washington, 99164, Meiji Seika Kaisha, Ltd., Pharmaceutical Research Center, Pharmacokin, 760 Morooka-cho, Kohoku-ku, Yokohama, Japan 222-8567, Department of Medicinal Chemistry, University of Washington, Box 357610, Seattle, Washington 98195-7610, and Department of Chemistry, Washington State University, P.O. Box 644630, Pullman, Washington 99164-4630

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm049605m

Reference31 articles.

1. Cytochrome P4502C9: an enzyme of major importance in human drug metabolism

2. Hydroxylation of warfarin by human cDNA-expressed cytochrome P-450: a role for P-4502C9 in the etiology of (S)-warfarin-drug interactions

3. Interaction of Sulfaphenazole Derivatives with Human Liver Cytochromes P450 2C: Molecular Origin of the Specific Inhibitory Effects of Sulfaphenazole on CYP 2C9 and Consequences for the Substrate Binding Site Topology of CYP 2C9

4. Potentiation of anticoagulant effect of warfarin caused by enantioselective metabolic inhibition by the uricosuric agent benzbromarone

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