A Practical Synthesis of Renin Inhibitor MK-1597 (ACT-178882) via Catalytic Enantioselective Hydrogenation and Epimerization of Piperidine Intermediate-Reference-Cited by-同舟云学术

A Practical Synthesis of Renin Inhibitor MK-1597 (ACT-178882) via Catalytic Enantioselective Hydrogenation and Epimerization of Piperidine Intermediate

Published:2011-01-20 Issue:4 Volume:76 Page:1062-1071
ISSN:0022-3263
Container-title:The Journal of Organic Chemistry
language:en
Short-container-title:J. Org. Chem.

Author:

Molinaro Carmela¹,Shultz Scott²,Roy Amélie¹,Lau Stephen¹,Trinh Thao¹,Angelaud Rémy¹,O’Shea Paul D.¹,Abele Stefan³,Cameron Mark²,Corley Ed²,Funel Jacques-Alexis³,Steinhuebel Dietrich²,Weisel Mark²,Krska Shane²

Affiliation:

1. Department of Process Research, Merck, 16711 Autoroute Transcanadienne, Kirkland, Québec, Canada H9H 3L1

2. Department of Process Research, Merck, P.O. Box 2000, Rahway, New Jersey 07065, United States

3. Department of Process Research Chemistry, Actelion Pharmaceuticals Ltd., Gewerbestrasse 16, 4123 Allschwil, Switzerland

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/jo102070e

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1. Maintenance of blood pressure by the renin–angiotensin system in normal man