Theoretical Studies Suggest a New Antifolate as a More Potent Inhibitor of Thymidylate Synthase-Reference-Cited by-同舟云学术

Theoretical Studies Suggest a New Antifolate as a More Potent Inhibitor of Thymidylate Synthase

Published:2000-04-25 Issue:18 Volume:122 Page:4385-4393
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Lee Tai-Sung¹,Kollman Peter A.¹

Affiliation:

1. Contribution from the Department of Pharmaceutical Chemistry, University of California, San Francisco, California 94143-0446

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

https://pubs.acs.org/doi/pdf/10.1021/ja9925554

Reference32 articles.

1. Structure-Based Design of Lipophilic Quinazoline Inhibitors of Thymidylate Synthase

2. Santi, D. V.; Danenberg, P. V. InChemistry and Biochemistry of Folates. Vol. 1:Folates and Pterins; Blakley, R. L., Benkovic, S. J., Eds.; John Wiley & Sons: New York, 1984; pp 345−398.

3. The renewed potential for folate antagonists in contemporary cancer chemotherapy

4. A potent antitumour quinazoline inhibitor of thymidylate synthetase: Synthesis, biological properties and therapeutic results in mice

5. Quinazoline antifolates inhibiting thymidylate synthase: variation of the N10 substituent

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