Isolation, Synthesis, and Semisynthesis of Amaryllidaceae Constituents from Narcissus and Galanthus sp.: De Novo Total Synthesis of 2-epi-Narciclasine-Reference-Cited by-同舟云学术

Isolation, Synthesis, and Semisynthesis of Amaryllidaceae Constituents from Narcissus and Galanthus sp.: De Novo Total Synthesis of 2-epi-Narciclasine

Published:2018-05-22 Issue:6 Volume:81 Page:1451-1459
ISSN:0163-3864
Container-title:Journal of Natural Products
language:en
Short-container-title:J. Nat. Prod.

Author:

Borra Suresh¹,Lapinskaite Ringaile²,Kempthorne Christine³,Liscombe David³,McNulty James¹^ORCID,Hudlicky Tomas²^ORCID

Affiliation:

1. Department of Chemistry & Chemical Biology, McMaster University, 1280 Main Street West, Hamilton, ON L8S 4M1, Canada

2. Department of Chemistry and Centre for Biotechnology, Brock University, 1812 Sir Isaac Brock Way, St. Catharines, ON L2S 3A1, Canada

3. Vineland Research and Innovation Centre, 4890 Victoria Avenue North, Box 4000, Vineland Station, ON L0R 2E0, Canada

Funder

Canada Foundation for Innovation

Agriculture and Agri-Food Canada

Canada Research Chairs

Stanley Medical Research Institute

Natural Sciences and Engineering Research Council of Canada

Advanced Biomanufacturing Centre, Brock University

Ontario Partnership for Innovation and Commercialization

TDC Research, Inc.

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Complementary and alternative medicine,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Analytical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jnatprod.8b00218

Reference35 articles.

1. Narciclasine: an Antimitotic Substance from Narcissus Bulbs

2. Narciclasine and narciprimine

3. The Amaryllidaceae Isocarbostyril Narciclasine Induces Apoptosis By Activation of the Death Receptor and/or Mitochondrial Pathways in Cancer Cells But Not in Normal Fibroblasts

4. Targeting of eEF1A withAmaryllidaceaeisocarbostyrils as a strategy to combat melanomas

5. Seasonal accumulation of major alkaloids in organs of pharmaceutical crop Narcissus Carlton

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