Bromopyrrole Alkaloid Inhibitors of the Proteasome Isolated from a Dictyonella sp. Marine Sponge Collected at the Amazon River Mouth

Author:

de Souza Renata T. M. P.1,Freire Vítor F.1ORCID,Gubiani Juliana R.1,Ferreira Raquel O.2,Trivella Daniela B. B.2,Moraes Fernando C.3,Paradas Wladimir C.3,Salgado Leonardo T.3,Pereira Renato C.34,Amado Filho Gilberto M.3,Ferreira Antonio G.5,Williams David E.6ORCID,Andersen Raymond J.6ORCID,Molinski Tadeusz F.7ORCID,Berlinck Roberto G. S.1ORCID

Affiliation:

1. Instituto de Química de São Carlos, Universidade de São Paulo, CP 780, CEP 13560-970, São Carlos, SP, Brazil

2. Brazilian Biosciences National Laboratory, National Center for Research in Energy and Material, Giuseppe Maximo Scolfaro, 10000, Pólo II de Alta Tecnologia de Campinas, 13083-970 Campinas, SP, Brazil

3. Instituto de Pesquisas Jardim Botânico do Rio de Janeiro, R. Pacheco Leão, 915, CEP 22460-030, Rio de Janeiro, RJ, Brazil

4. Departamento de Biologia Marinha, Instituto de Biologia, Universidade Federal Fluminense (UFF), P.O.Box 100.644, CEP 24001-970, Niteroi, RJ, Brazil

5. Departamento de Química, Universidade Federal de São Carlos, Rod. Washington Luiz, km 235 - SP-310, CEP 13565-905, São Carlos, SP, Brazil

6. Departments of Chemistry and Earth, Ocean and Atmospheric Sciences, University of British Columbia, Vancouver, BC V6T 1Z1, Canada

7. Department of Chemistry and Biochemistry and Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Drive MC-0358, La Jolla, California 92093-0358, United States

Funder

Ag?ncia Nacional do Petr?leo, G?s Natural e Biocombust?veis

Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico

Funda??o de Amparo ? Pesquisa do Estado de S?o Paulo

Funda??o Carlos Chagas Filho de Amparo ? Pesquisa do Estado do Rio de Janeiro

Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Complementary and alternative medicine,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Analytical Chemistry

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