Betulinic Acid Inhibits RANKL-Induced Osteoclastogenesis via Attenuating Akt, NF-κB, and PLCγ2-Ca2+ Signaling and Prevents Inflammatory Bone Loss

Author:

Jeong Da Hye1,Kwak Sung Chul2,Lee Myeung Su13,Yoon Kwon-Ha45,Kim Ju-Young35ORCID,Lee Chang Hoon15

Affiliation:

1. Division of Rheumatology, Department of Internal Medicine, School of Medicine, Wonkwang University, 460 Iksandae-ro, Iksan, Jeonbuk 54538, Republic of Korea

2. Department of Anatomy, School of Medicine, Wonkwang University, 460 Iksandae-ro, Iksan, Jeonbuk 54538, Republic of Korea

3. Musculoskeletal and Immune Disease Research Institute, School of Medicine, Wonkwang University, 460 Iksandae-ro, Iksan, Jeonbuk 54538, Republic of Korea

4. Department of Radiology, School of Medicine, Wonkwang University, 460 Iksandae-ro, Iksan, Jeonbuk 54538, Republic of Korea

5. Medical Convergence Research Center, Wonkwang University Hospital, 460 Iksandae-ro, Iksan, Jeonbuk 54538, Republic of Korea

Funder

Wonkwang University

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Complementary and alternative medicine,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Analytical Chemistry

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