Anti-SARS-CoV-2 Activity of Andrographis paniculata Extract and Its Major Component Andrographolide in Human Lung Epithelial Cells and Cytotoxicity Evaluation in Major Organ Cell Representatives

Author:

Sa-ngiamsuntorn Khanit1ORCID,Suksatu Ampa2,Pewkliang Yongyut3ORCID,Thongsri Piyanoot3,Kanjanasirirat Phongthon4,Manopwisedjaroen Suwimon2,Charoensutthivarakul Sitthivut456ORCID,Wongtrakoongate Patompon67,Pitiporn Supaporn8,Chaopreecha Jarinya2,Kongsomros Supasek2,Jearawuttanakul Kedchin4,Wannalo Warawuth4,Khemawoot Phisit9,Chutipongtanate Somchai910,Borwornpinyo Suparerk411,Thitithanyanont Arunee2,Hongeng Suradej410

Affiliation:

1. Department of Biochemistry, Faculty of Pharmacy, Mahidol University, Bangkok 10400, Thailand

2. Department of Microbiology, Faculty of Science, Mahidol University, Bangkok 10400, Thailand

3. Section for Translational Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand

4. Excellent Center for Drug Discovery (ECDD), Faculty of Science, Mahidol University, Bangkok 10400, Thailand

5. School of Bioinnovation and Bio-Based Product Intelligence, Faculty of Science, Mahidol University, Bangkok 10400, Thailand

6. Center for Neuroscience, Faculty of Science, Mahidol University, Bangkok 10400, Thailand

7. Department of Biochemistry, Faculty of Science, Mahidol University, Bangkok 10400,Thailand

8. ChaoPhya Abhaibhubejhr Hospital, Prachin Buri 25000, Thailand

9. Chakri Naruebodindra Medical Institute, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Samutprakarn 10540, Thailand

10. Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand

11. Department of Biotechnology, Faculty of Science, Mahidol University, Bangkok 10400, Thailand

Funder

Thailand Center of Excellence for Life Sciences

Thailand Research Fund

Mahidol University

Faculty of Science, Mahidol University

Chao Phraya Abhaibhubejhr Hospital Foundation

Faculty of Medicine Ramathibodi Hospital, Mahidol University

Office of National Higher Education Science Research and Innovation Policy Council

Ramathibodi Foundation

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Complementary and alternative medicine,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Analytical Chemistry

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