Discovery of a Remarkable Methyl Shift Effect in the Vanilloid Activity of Triterpene Amides-Reference-Cited by-同舟云学术

Discovery of a Remarkable Methyl Shift Effect in the Vanilloid Activity of Triterpene Amides

Published:2020-11-02 Issue:11 Volume:83 Page:3476-3481
ISSN:0163-3864
Container-title:Journal of Natural Products
language:en
Short-container-title:J. Nat. Prod.

Author:

Vitale Rosa Maria¹^ORCID,Avonto Cristina²,Del Prete Danilo³^ORCID,Moriello Aniello Schiano⁴⁵,Amodeo Pietro¹^ORCID,Appendino Giovanni³^ORCID,De Petrocellis Luciano⁴

Affiliation:

1. Institute of Biomolecular Chemistry, National Research Council (ICB-CNR), Via Campi Flegrei 34, 80078 Pozzuoli (NA), Italy

2. National Center for Natural Products Research, Research Institute of Pharmaceutical Science, School of Pharmacy, The University of Mississippi, University, Mississippi 38677, United States

3. Dipartimento di Scienze del Farmaco, Università del Piemonte Orientale, Largo Donegani 2, 28100 Novara, Italy

4. Endocannabinoid Research Group (ERG), Institute of Biomolecular Chemistry, National Research Council (ICB-CNR), Via Campi Flegrei 34, 80078 Pozzuoli (NA), Italy

5. Epitech Group SpA, Saccolongo, Padova, Italy

Funder

Ministero dell?Istruzione, dell?Universit? e della Ricerca

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Complementary and alternative medicine,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Analytical Chemistry

Link

http://pubs.acs.org/doi/pdf/10.1021/acs.jnatprod.0c00639

Reference27 articles.

1. The capsaicin receptor: a heat-activated ion channel in the pain pathway

2. Vitale, R. M.; Schiano Moriello, A.; De Petrocellis, L. Natural Compounds and Synthetic Drugs Targeting the Ionotropic Cannabinoid Members of Transient Receptor Potential (TRP) Channels. In New Tools to Interrogate Endocannabinoid Signalling - From Natural Compounds to Synthetic Drugs; Maccarrone, M., Ed. RSC, 2020; in press.

3. TRPV1 structures in distinct conformations reveal activation mechanisms

4. Structure of the TRPV1 ion channel determined by electron cryo-microscopy

5. TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action

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