Production of Highly Active Antiparasitic Compounds from the Controlled Halogenation of the Arrabidaea brachypoda Crude Plant Extract

Author:

Neuenschwander Alexandra1,Rocha Vinicius P. C.2,Bastos Tanira M.2,Marcourt Laurence1ORCID,Morin Hugo1,da Rocha Cláudia Q.3ORCID,Grimaldi Gabriela B.2,de Sousa Karoline A. F.2,Borges Jadson N.2,Rivara-Minten Elisabeth1,Wolfender Jean-Luc1ORCID,Soares Milena B. P.2ORCID,Queiroz Emerson F.1ORCID

Affiliation:

1. School of Pharmaceutical Sciences and Institute of Pharmaceutical Sciences of Western Switzerland (ISPSW), University of Geneva, CMU, Rue Michel Servet 1, 1211 Geneva 4, Switzerland

2. Laboratório de Engenharia Tecidual e Imunofarmacologia. Instituto Gonçalo Moniz, FIOCRUZ, Rua Waldemar Falcão, 121, Candeal, Salvador, BA 40296-710, Brazil

3. Laboratório de Produtos Naturais, Centro de Ciência Exatas e Tecnologia, Departamento de Química, Avenida dos Portugueses 1966, Bacanga, São Luís, Maranhão, MA 65080-805, Brazil

Funder

Schweizerischer Nationalfonds zur F?rderung der Wissenschaftlichen Forschung

Funda??o de Amparo ? Pesquisa do Estado da Bahia

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Complementary and alternative medicine,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Analytical Chemistry

Reference25 articles.

1. Fragment-based drug discovery as alternative strategy to the drug development for neglected diseases

2. WHO. Neglected Tropical Diseases; World Health Organization: Geneva, Switzerland, 2018.

3. WHO. Chagas Disease:Control and Elimination; World Health Organization: Geneva, Switzerland, 2010.

4. A Critical Review on Chagas Disease Chemotherapy

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