Phorbol Esters from the Latex of Euphorbia umbellata: Bioguided Isolation of Highly Potent HIV-1 Latency Interrupters in Virus Reservoir Cells

Author:

Tostes João B. F.1,Carvalho Andressa L. D.1,Ribeiro da Silva Antonio J.2,Mourão Pedro Junior P.3,Rossi Átila D.3,Tanuri Amílcar3,Siani Antonio C.1ORCID

Affiliation:

1. Institute of Drug Technology, Oswaldo Cruz Foundation, Rua Sizenando Nabuco 100, 21041-250, Rio de Janeiro, RJ, Brazil

2. Natural Products Research Institute, Federal University of Rio de Janeiro, CCS, Bl. H, Ilha do Fundão, 21941-902, Rio de Janeiro, RJ, Brazil

3. Laboratory of Molecular Virology, Institute of Biology, Federal University of Rio de Janeiro, Avenida Carlos Chagas Filho 373, 21941-902, Rio de Janeiro, RJ, Brazil

Funder

Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Complementary and alternative medicine,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Analytical Chemistry

Reference35 articles.

1. bBruneton, J. Toxic Plants Dangerous to Humans and Animals; Intercept Limited: Andover, UK, 1999; p 267.

2. Irritant plants in the spurge family (Euphorbiaceae)

3. Neuwinger, H. D. African Ethnobotany: Poisons and Drugs: Chemistry, Pharmacology, Toxicology; Chapman & Hall GmbH: Weinheim, 1996; pp 521–522.

4. Africa Museum, Tervuren Belgium. Prelude Medicinal Plants Database. https://www.africamuseum.be/en/research/collections_libraries/biology/prelude/view_plant?pi=12130 (accessed March 17, 2020).

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