A Homodimer of Withaferin A Formed by Base-Promoted Elimination of Acetic Acid from 27-<i>O</i>-Acetylwithaferin A Followed by a Diels

A Homodimer of Withaferin A Formed by Base-Promoted Elimination of Acetic Acid from 27-O-Acetylwithaferin A Followed by a Diels–Alder Reaction

Published:2024-02-28 Issue:3 Volume:87 Page:583-590
ISSN:0163-3864
Container-title:Journal of Natural Products
language:en
Short-container-title:J. Nat. Prod.

Author:

Wijeratne E. M. Kithsiri¹,Xu Ya-Ming¹,Padumadasa Chayanika¹²,Astashkin Andrei V.³,Gunatilaka A. A. Leslie¹^ORCID

Affiliation:

1. Southwest Center for Natural Products Research, School of Natural Resources and the Environment, College of Agriculture, Life and Environmental Sciences, University of Arizona, 1064 E. Lowell Street, Tucson, Arizona 85719, United States

2. Department of Chemistry, Faculty of Applied Sciences, University of Sri Jayewardenepura, Gangodawila, Nugegoda 10250, Sri Lanka

3. Department of Chemistry and Biochemistry, University of Arizona, Tucson, Arizona 85721, United States

Funder

University of Arizona

Council for International Exchange of Scholars

Fulbright Program

Institute of International Education

Arizona Biomedical Research Commission

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jnatprod.3c01003

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4. Withaferin A Strongly Elicits IκB Kinase β Hyperphosphorylation Concomitant with Potent Inhibition of Its Kinase Activity

5. Notch-1 Inhibition by Withaferin-A: A Therapeutic Target against Colon Carcinogenesis