Appraisal of Fungus-Derived Xanthoquinodins as Broad-Spectrum Anti-Infectives Targeting Phylogenetically Diverse Human Pathogens

Author:

Lee Jin Woo1,Collins Jennifer E.2ORCID,Hulverson Matthew A.3ORCID,Aguila Laarni Kendra T.4,Kim Caroline M.4,Wendt Karen L.1,Chakrabarti Debopam2,Ojo Kayode K.3,Wood Gwendolyn E.4,Van Voorhis Wesley C.3ORCID,Cichewicz Robert H.1ORCID

Affiliation:

1. Natural Products Discovery Group, Institute for Natural Products Applications and Research Technologies, Department of Chemistry and Biochemistry, Stephenson Life Sciences Research Center, University of Oklahoma, Norman, Oklahoma 73019, United States

2. Division of Molecular Microbiology, Burnett School of Biomedical Sciences, University of Central Florida, Orlando, Florida 32826, United States

3. Center for Emerging and Re-emerging Infectious Diseases (CERID), Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, 358061, 750 Republican Street, Seattle, Washington 98109, United States

4. Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington 98104, United States

Funder

National Institute of Allergy and Infectious Diseases

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Complementary and alternative medicine,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Analytical Chemistry

Reference40 articles.

1. Compound Summary for CID 41684, Nitazoxanide. PubChem; National Library of Medicine (US), 2023. https://pubchem.ncbi.nlm.nih.gov/compound/Nitazoxanide (accessed March 8, 2023).

2. Compound Summary for CID 165580, Paromomycin. PubChem; National Library of Medicine (US), 2023. https://pubchem.ncbi.nlm.nih.gov/compound/Paromomycin (accessed March 8, 2023).

3. Compound Summary for CID 5479, Tinidazole. PubChem; National Library of Medicine (US), 2023. https://pubchem.ncbi.nlm.nih.gov/compound/Tinidazole (accessed March 8, 2023).

4. Diarylureas: Repositioning from Antitumor to Antimicrobials or Multi-Target Agents against New Pandemics

5. Clofazimine for the treatment of tuberculosis

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