Discovery of an Unexpected 1,4-Oxazepine-Linked seco-Fluostatin Heterodimer by Inactivation of the Oxidoreductase-Encoding Gene flsP-Reference-Cited by-同舟云学术

Discovery of an Unexpected 1,4-Oxazepine-Linked seco-Fluostatin Heterodimer by Inactivation of the Oxidoreductase-Encoding Gene flsP

Published:2021-08-12 Issue:8 Volume:84 Page:2336-2344
ISSN:0163-3864
Container-title:Journal of Natural Products
language:en
Short-container-title:J. Nat. Prod.

Author:

Huang Chunshuai¹²,Yang Chunfang¹²³⁴,Zhang Wenjun¹²³⁴^ORCID,Zhang Liping¹³⁴,Zhu Yiguang¹²³⁴^ORCID,Zhang Changsheng¹²³⁴^ORCID

Affiliation:

1. Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, Innovation Academy of South China Sea Ecology and Environmental Engineering, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, China

2. University of Chinese Academy of Sciences, 19 Yuquan Road, Beijing 100049, China

3. Sanya Institute of Oceanology, SCSIO, Yazhou Scientific Bay, Sanya 572000, China

4. Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), 1119 Haibin Road, Nansha District, Guangzhou 511458, China

Funder

National Natural Science Foundation of China

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Complementary and alternative medicine,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Analytical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jnatprod.1c00461

Reference39 articles.

1. Angucyclines: Biosynthesis, mode-of-action, new natural products, and synthesis

2. Identification of Alp1U and Lom6 as epoxy hydrolases and implications for kinamycin and lomaiviticin biosynthesis

3. The cytotoxicity of (−)-lomaiviticin A arises from induction of double-strand breaks in DNA

4. Structure Revision of the Lomaiviticins

5. Isolation, structure elucidation and biosynthesis of benzo[b]fluorene nenestatin A from deep-sea derived Micromonospora echinospora SCSIO 04089

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