Target-Based Virtual Screening and LC/MS-Guided Isolation Procedure for Identifying Phloroglucinol-Terpenoid Inhibitors of SARS-CoV-2

Author:

Hou Bo1ORCID,Zhang Yu-Min2,Liao Han-Yi3,Fu Li-Feng3,Li De-Dong3,Zhao Xin3,Qi Jian-Xun3,Yang Wei3,Xiao Geng-Fu2,Yang Lian1,Zuo Zheng-Yu1,Wang Lin4,Zhang Xiang-Lei4,Bai Fang4ORCID,Yang Liu1,Gao George F.3,Song Hao35,Hu Jiang-Miao1ORCID,Shang Wei-Juan2,Zhou Jun1

Affiliation:

1. State Key Laboratory of Phytochemistry and Plant Resources in West China and Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People’s Republic of China

2. State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan 430071, People’s Republic of China

3. CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, People’s Republic of China

4. Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, Shanghai Tech University, Shanghai 201210, People’s Republic of China

5. Research Network of Immunity and Health (RNIH), Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing 100101, People’s Republic of China

Funder

Yunnan Provincial Science and Technology Department

China Postdoctoral Science Foundation

Chinese Academy of Sciences

Postdoctoral Directional Training Foundation of Yunnan Province

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Complementary and alternative medicine,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Analytical Chemistry

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