Hypocholesterolemic Efficacy of Secoisolariciresinol Diglucoside and Its Polymer in Rat

Author:

Guo Yajia12,Yang Xiaolei2,Tse Timothy J.1ORCID,Purdy Sarah K.1,Mustafa Rana1,Shen Jianheng1,Alcorn Jane2,Reaney Martin J. T.134

Affiliation:

1. Department of Plant Sciences, University of Saskatchewan, 51 Campus Drive, Saskatoon, SK S7N 5A8, Canada

2. College of Pharmacy and Nutrition, University of Saskatchewan, 107 Wiggins Road, Saskatoon, SK S7N 5E5, Canada

3. Prairie Tide Diversified Inc., 102 Melville Street, Saskatoon, SK S7J 0R1, Canada

4. Guangdong Saskatchewan Oilseed Joint Laboratory, Department of Food Science and Engineering, Jinan University, 601 Huangpu Avenue West, Guangzhou, Guangdong 510632, China

Funder

Natural Sciences and Engineering Research Council of Canada

Mitacs

Saskatchewan Agricultural Development Fund

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Complementary and alternative medicine,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Analytical Chemistry

Reference52 articles.

1. The beneficial effects of nutraceuticals and natural products on small dense LDL levels, LDL particle number and LDL particle size: a clinical review

2. Health Canada (2014) Summary of Health Canada’s assessment of a health claim about ground whole flaxseed and blood cholesterol lowering. https://www.canada.ca/en/health-canada/services/food-nutrition/food-labelling/health-claims/assessments/ground-whole-flaxseed-blood-cholesterol-lowering-nutrition-health-claims-food-labelling.html (accessed March 2021).

3. Flaxseed lignan lowers blood cholesterol and decreases liver disease risk factors in moderately hypercholesterolemic men

4. Effects of the flaxseed lignans secoisolariciresinol diglucoside and its aglycone on serum and hepatic lipids in hyperlipidaemic rats

5. Secoisolariciresinol Diglucoside: Relevance to Angiogenesis and Cardioprotection against Ischemia-Reperfusion Injury

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