1. Drug Discovery Shandong Laboratory, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai, Shandong 264117, P. R. China
2. Key Laboratory of Marine Drugs, The Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, P. R. China
3. State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai, 201203, P. R. China
4. University of Chinese Academy of Sciences, No.19A Yuquan Road, Beijing 100049, P. R. China
5. Jealott’s Hill International Research Centre, Syngenta, Bracknell, Berkshire RG42 6EY, United Kingdom