A <i>Streptomyces</i> Cytochrome P450 Enzyme Catalyzes Regiospecific <i>C</i>2-Guaninylation for the Synthesis of Diverse Guanitrypmycin Analogs-Reference-Cited by-同舟云学术

A Streptomyces Cytochrome P450 Enzyme Catalyzes Regiospecific C2-Guaninylation for the Synthesis of Diverse Guanitrypmycin Analogs

Published:2023-01-04 Issue:1 Volume:86 Page:94-102
ISSN:0163-3864
Container-title:Journal of Natural Products
language:en
Short-container-title:J. Nat. Prod.

Author:

Liu Jing¹,Yang Yiling¹,Xie Xiulan²,Li Shu-Ming¹^ORCID

Affiliation:

1. Institut für Pharmazeutische Biologie und Biotechnologie, Fachbereich Pharmazie, Philipps-Universität Marburg, Robert-Koch Straße 4, 35037 Marburg, Germany

2. Fachbereich Chemie, Philipps-Universität Marburg, Hans-Meerwein-Straße 4, 35032 Marburg, Germany

Funder

Deutsche Forschungsgemeinschaft

China Scholarship Council

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Complementary and alternative medicine,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Analytical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jnatprod.2c00787

Reference34 articles.

1. Natural products in drug discovery: advances and opportunities

2. Mining microbial genomes for new natural products and biosynthetic pathways

3. The secreted metabolome of Streptomyces chartreusis and implications for bacterial chemistry

4. The expanding spectrum of diketopiperazine natural product biosynthetic pathways containing cyclodipeptide synthases

5. Modifications of diketopiperazines assembled by cyclodipeptide synthases with cytochrome P450 enzymes

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4. P450 in C–C coupling of cyclodipeptides with nucleobases;Methods in Enzymology;2023