Iterative Methylation Leads to 3-Methylchuangxinmycin Production in <i>Actinoplanes tsinanensis</i> CPCC 200056-Reference-Cited by-同舟云学术

Iterative Methylation Leads to 3-Methylchuangxinmycin Production in Actinoplanes tsinanensis CPCC 200056

Published:2023-01-17 Issue:1 Volume:86 Page:1-7
ISSN:0163-3864
Container-title:Journal of Natural Products
language:en
Short-container-title:J. Nat. Prod.

Author:

Hu Xiaomin¹,Shi Yuanyuan¹,Jiang Bingya¹^ORCID,Fu Jie¹,Li Xingxing¹,Li Shufen¹,Sun Guizhi¹,Ren Weicong¹,Hu Xinxin¹,You Xuefu¹,Liu Zhiyong²,Han Xingli²,Zhang Tianyu²^ORCID,Hong Bin¹,Wu Linzhuan¹^ORCID

Affiliation:

1. NHC Key Laboratory of Biotechnology of Antibiotics, and CAMS Key Laboratory of Synthetic Biology for Drug Innovation, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, People’s Republic of China

2. State Key Laboratory of Respiratory Disease, China-New Zealand Joint Laboratory of Biomedicine and Health, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, People’s Republic of China

Funder

Ministry of Science and Technology of the People's Republic of China

Chinese Academy of Medical Sciences

National Natural Science Foundation of China

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Complementary and alternative medicine,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Analytical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jnatprod.2c00360

Reference32 articles.

1. The antimicrobial natural product chuangxinmycin and Some synthetic analogues are potent and selective inhibitors of bacterial tryptophanyl tRNA synthetase

2. Biosynthesis of antibiotic chuangxinmycin from Actinoplanes tsinanensis

3. Heterologous Expression Guides Identification of the Biosynthetic Gene Cluster of Chuangxinmycin, an Indole Alkaloid Antibiotic

4. The Cytochrome P450 Catalyzing C−S Bond Formation in S ‐Heterocyclization of Chuangxinmycin Biosynthesis

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