Thiazolidinedione-Based Structure Modification of Celastrol Provides Thiazolidinedione-Conjugated Derivatives as Potent Agents against Non-Small-Cell Lung Cancer Cells through a Mitochondria-Mediated Apoptotic Pathway

Author:

Fu Xuefeng1,Mao Qing1,Zhang Bing1,Lv Jialun1,Ping Kunqi1,Zhang Peng1,Lin Fengwei1,Zhao Jiaxing1,Feng Yao12,Yang Jincheng2,Wang Huiyu2,Zhang Lei3,Mou Yanhua4,Wang Shaojie1ORCID

Affiliation:

1. Key Laboratory of Structure-Based Drugs Design & Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Culture Road, Shenhe District, Shenyang 110016, China

2. Ningxia Kangya Pharmaceutical Co., Ltd., Yinchuan 750000, China

3. Department of Neurosurgery, Shengjing Hospital of China Medical University, Shenyang 110016, China

4. Department of Pharmacology, Shenyang Pharmaceutical University, 103 Culture Road, Shenhe District, Shenyang 110016, China

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Complementary and alternative medicine,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Analytical Chemistry

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