Identification of Natural Products Inhibiting SARS-CoV-2 by Targeting Viral Proteases: A Combined in Silico and in Vitro Approach-Reference-Cited by-同舟云学术

Identification of Natural Products Inhibiting SARS-CoV-2 by Targeting Viral Proteases: A Combined in Silico and in Vitro Approach

Published:2023-01-18 Issue:2 Volume:86 Page:264-275
ISSN:0163-3864
Container-title:Journal of Natural Products
language:en
Short-container-title:J. Nat. Prod.

Author:

Wasilewicz Andreas¹²,Kirchweger Benjamin¹^ORCID,Bojkova Denisa³,Abi Saad Marie Jose¹²,Langeder Julia¹²,Bütikofer Matthias⁴,Adelsberger Sigrid¹²^ORCID,Grienke Ulrike¹^ORCID,Cinatl Jr. Jindrich³,Petermann Olivier⁵⁶,Scapozza Leonardo⁵⁶,Orts Julien¹^ORCID,Kirchmair Johannes¹^ORCID,Rabenau Holger F.³,Rollinger Judith M.¹^ORCID

Affiliation:

1. Department of Pharmaceutical Sciences, University of Vienna, Josef-Holaubek-Platz 2, 1090 Vienna, Austria

2. Vienna Doctoral School of Pharmaceutical, Nutritional and Sport Sciences, University of Vienna, Josef-Holaubek-Platz 2, 1090 Vienna, Austria

3. Institute of Medical Virology, University Hospital Frankfurt, Paul-Ehrlich-Straße 40, 60596 Frankfurt am Main, Germany

4. Swiss Federal Institute of Technology, Laboratory of Physical Chemistry, ETH Zurich, Vladimir-Prelog-Weg 1-5/10, 8093 Zurich, Switzerland

5. Pharmaceutical Biochemistry Group, School of Pharmaceutical Sciences, University of Geneva, 1205 Geneva, Switzerland

6. Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, 1205 Geneva, Switzerland

Funder

Schweizerischer Nationalfonds zur F?rderung der Wissenschaftlichen Forschung

Austrian Science Fund

Swiss Cancer Research Foundation

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Complementary and alternative medicine,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Analytical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jnatprod.2c00843

Reference65 articles.

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3. Increased immune escape of the new SARS-CoV-2 variant of concern Omicron

4. Perspectives on SARS-CoV-2 Main Protease Inhibitors

5. β-d-N4-hydroxycytidine Inhibits SARS-CoV-2 Through Lethal Mutagenesis But Is Also Mutagenic To Mammalian Cells

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