Dihydromaniwamycin E, a Heat-Shock Metabolite from Thermotolerant Streptomyces sp. JA74, Exhibiting Antiviral Activity against Influenza and SARS-CoV-2 Viruses

Author:

Saito Shun1,Funayama Kayo1,Kato Wataru1,Okuda Mayu1,Kawamoto Meiko1,Matsubara Teruhiko1ORCID,Sato Toshinori1ORCID,Sato Akihiko23,Otsuguro Satoko4,Sasaki Michihito3,Orba Yasuko35,Sawa Hirofumi3567,Maenaka Katsumi4,Shindo Kazutoshi8ORCID,Imoto Masaya9,Arai Midori A.1ORCID

Affiliation:

1. Department of Biosciences and Informatics, Faculty of Science and Technology, Keio University, Yokohama 223-8522, Japan

2. Drug Discovery and Disease Research Laboratory, Shionogi & Co., Ltd., Osaka 541-0045, Japan

3. Division of Molecular Pathobiology, International Institute for Zoonosis Control, Hokkaido University, Sapporo 001-0020, Japan

4. Laboratory of Biomolecular Science, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan

5. International Collaboration Unit, International Institute for Zoonosis Control, Hokkaido University, Sapporo 001-0020, Japan

6. One Health Research Center, Hokkaido University, Sapporo 060-0818, Japan

7. Global Virus Network, Baltimore, Maryland 21201, United States

8. Department of Food and Nutrition, Japan Women’s University, Tokyo 112-8681, Japan

9. Department of Neurology, Juntendo University School of Medicine, Tokyo 113-8431, Japan

Funder

Naito Foundation

Institute for Fermentation, Osaka

Japan Agency for Medical Research and Development

Tokyo Biochemical Research Foundation

Japan Society for the Promotion of Science

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Complementary and alternative medicine,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Analytical Chemistry

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