Structure- and Property-Based Design of Aminooxazoline Xanthenes as Selective, Orally Efficacious, and CNS Penetrable BACE Inhibitors for the Treatment of Alzheimer’s Disease-Reference-Cited by-同舟云学术

Structure- and Property-Based Design of Aminooxazoline Xanthenes as Selective, Orally Efficacious, and CNS Penetrable BACE Inhibitors for the Treatment of Alzheimer’s Disease

Published:2012-09-11 Issue:21 Volume:55 Page:9156-9169
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Huang Hongbing¹²,La Daniel S.¹²,Cheng Alan C.¹²,Whittington Douglas A.¹²,Patel Vinod F.¹²,Chen Kui¹²,Dineen Thomas A.¹²,Epstein Oleg¹²,Graceffa Russell¹²,Hickman Dean¹²,Kiang Y.-H.¹²,Louie Steven¹²,Luo Yi¹²,Wahl Robert C.¹²,Wen Paul H.¹²,Wood Stephen¹²,Fremeau Robert T.¹²

Affiliation:

1. Department of Medicinal Chemistry and ‡Department of Molecular Structure, Amgen Inc., 360 Binney Street, Cambridge, Massachusetts 02142, United States

2. Department of Neuroscience, ∥Department of Pharmacokinetics and Drug Metabolism, ⊥Department of HTS and Molecular Pharmacology, and #Department of Pharmaceutics, Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 91320, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm300598e

Reference75 articles.

1. Biomarkers in Alzheimer's disease drug development

2. Alzheimer's Disease

3. Alzheimer's disease: strategies for disease modification

4. Alzheimer's Disease: From Pathology to Therapeutic Approaches

5. Recent Developments in Tau-Based Therapeutics for Neurodegenerative Diseases

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