Design, Synthesis, and Evaluation of Conformationally Restricted Acetanilides as Potent and Selective β3Adrenergic Receptor Agonists for the Treatment of Overactive Bladder-Reference-Cited by-同舟云学术

Design, Synthesis, and Evaluation of Conformationally Restricted Acetanilides as Potent and Selective β3Adrenergic Receptor Agonists for the Treatment of Overactive Bladder

Published:2014-02-05 Issue:4 Volume:57 Page:1437-1453
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Moyes Christopher R.¹,Berger Richard²,Goble Stephen D.³,Harper Bart³,Shen Dong-Ming³,Wang Liping³,Bansal Alka³,Brown Patricia N.¹,Chen Airu S.³,Dingley Karen H.¹,Di Salvo Jerry¹,Fitzmaurice Aileen¹,Gichuru Loise N.¹,Hurley Amanda L.³,Jochnowitz Nina¹,Miller Randall R.¹,Mistry Shruty³,Nagabukuro Hiroshi³,Salituro Gino M.³,Sanfiz Anthony³,Stevenson Andra S.¹,Villa Katherine³,Zamlynny Beata¹,Struthers Mary¹,Weber Ann E.¹,Edmondson Scott D.¹

Affiliation:

1. Early Development and Discovery Sciences, Merck and Co., Inc., 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States

2. Early Development and Discovery Sciences, Merck and Co., Inc., 770 Sumneytown Pike, West Point, Pennsylvania 19486, United States

3. Early Development and Discovery Sciences, Merck and Co., Inc., 126 East Lincoln Avenue, Rahway, New Jersey 07065, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm4017224

Reference32 articles.

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4. β3 Adrenergic Receptor Agonists for the Treatment of Obesity

5. Population-Based Survey of Urinary Incontinence, Overactive Bladder, and Other Lower Urinary Tract Symptoms in Five Countries: Results of the EPIC Study

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