Design, Synthesis, and Biological Evaluation of the Combinatorial Library with a New Spirodiketopiperazine Scaffold. Discovery of Novel Potent and Selective Low-Molecular-Weight CCR5 Antagonists-Reference-Cited by-同舟云学术

Design, Synthesis, and Biological Evaluation of the Combinatorial Library with a New Spirodiketopiperazine Scaffold. Discovery of Novel Potent and Selective Low-Molecular-Weight CCR5 Antagonists

Published:2006-06-14 Issue:14 Volume:49 Page:4140-4152
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Habashita Hiromu¹,Kokubo Masaya¹,Hamano Shin-ichi¹,Hamanaka Nobuyuki¹,Toda Masaaki¹,Shibayama Shiro¹,Tada Hideaki¹,Sagawa Kenji¹,Fukushima Daikichi¹,Maeda Kenji¹,Mitsuya Hiroaki¹

Affiliation:

1. Medicinal Chemistry Research Laboratories, Ono Pharmaceutical Co., Ltd., Osaka 618-8585, Japan, Exploratory Research Laboratories, Ono Pharmaceutical Co., Ltd., Ibaraki 300-4247, Japan, Department of Internal Medicine II, Kumamoto University School of Medicine, Kumamoto 860-0811, Japan, and Experimental Retrovirology Section, HIV & AIDS Malignancy Branch, NCI, National Institutes of Health, Bethesda, Maryland 20892

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm060051s

Reference33 articles.

1. HIV-1 Entry Cofactor: Functional cDNA Cloning of a Seven-Transmembrane, G Protein-Coupled Receptor

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4. CC CKR5: A RANTES, MIP-1α, MIP-1β Receptor as a Fusion Cofactor for Macrophage-Tropic HIV-1

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