First X-ray Cocrystal Structure of a Bacterial FabH Condensing Enzyme and a Small Molecule Inhibitor Achieved Using Rational Design and Homology Modeling-Reference-Cited by-同舟云学术

First X-ray Cocrystal Structure of a Bacterial FabH Condensing Enzyme and a Small Molecule Inhibitor Achieved Using Rational Design and Homology Modeling

Published:2002-12-02 Issue:1 Volume:46 Page:5-8
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Daines Robert A.¹,Pendrak Israil¹,Sham Kelvin¹,Van Aller Glenn S.¹,Konstantinidis Alex K.¹,Lonsdale John T.¹,Janson Cheryl A.¹,Qiu Xiayang¹,Brandt Martin¹,Khandekar Sanjay S.¹,Silverman Carol¹,Head Martha S.¹

Affiliation:

1. Departments of Medicinal Chemistry, Computational, Analytical & Structural Sciences, Microbial Biochemistry, Assay Methodology Development, and Protein Biochemistry, GlaxoSmithKline, 1250 S. Collegeville Road, Collegeville, Pennsylvania 19426

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm025571b

Reference10 articles.

1. Purification and characterization of 3-ketoacyl-acyl carrier protein synthase III from spinach. A condensing enzyme utilizing acetyl-coenzyme A to initiate fatty acid synthesis.

2. Regulation of fatty acid biosynthesis in Escherichia coli.

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