Discovery of Orally Efficacious Melanin-Concentrating Hormone Receptor-1 Antagonists as Antiobesity Agents. Synthesis, SAR, and Biological Evaluation of Bicyclo[3.1.0]hexyl Ureas-Reference-Cited by-同舟云学术

Discovery of Orally Efficacious Melanin-Concentrating Hormone Receptor-1 Antagonists as Antiobesity Agents. Synthesis, SAR, and Biological Evaluation of Bicyclo[3.1.0]hexyl Ureas

Published:2006-03-07 Issue:7 Volume:49 Page:2294-2310
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

McBriar Mark D.¹,Guzik Henry¹,Shapiro Sherry¹,Paruchova Jaroslava¹,Xu Ruo¹,Palani Anandan¹,Clader John W.¹,Cox Kathleen¹,Greenlee William J.¹,Hawes Brian E.¹,Kowalski Timothy J.¹,O'Neill Kim¹,Spar Brian D.¹,Weig Blair¹,Weston Daniel J.¹,Farley Constance¹,Cook John¹

Affiliation:

1. Department of Chemical Research and Department of Cardiovascular and Metabolic Diseases, Schering-Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033-0539

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm050886n

Reference51 articles.

1. Prevalence of Obesity, Diabetes, and Obesity-Related Health Risk Factors, 2001

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