Normal-Phase Automated Mass-Directed HPLC Purification of a Pyrrolobenzodiazepine Library with Vasopressin Agonist Activity-Reference-Cited by-同舟云学术

Normal-Phase Automated Mass-Directed HPLC Purification of a Pyrrolobenzodiazepine Library with Vasopressin Agonist Activity

Published:2009-05-21 Issue:4 Volume:11 Page:704-719
ISSN:1520-4766
Container-title:Journal of Combinatorial Chemistry
language:en
Short-container-title:J. Comb. Chem.

Author:

Kagan Michael¹,Chlenov Michael¹,Melnikov Sergey¹,McConnell Oliver¹,Bach Alvin C.¹,Carter Guy¹,Failli Amedeo¹,Caggiano Thomas J.¹,Shumsky Jay S.¹,Lubda Dieter¹

Affiliation:

1. Discovery Analytical Chemistry, Chemical Technologies, Wyeth Research, CN 8000, Princeton, New Jersey 08543, Chemical and Screening Sciences, Wyeth Research, CN 8000, Princeton, New Jersey 08543, Discovery Analytical Chemistry, Chemical Technologies, Wyeth Research, 500 Arcola Road, Collegeville, Pennsylvania 19426, Discovery Analytical Chemistry, Chemical Technologies, Wyeth Pharmaceuticals, 401 N. Middletown Rd, Pearl River, New York 10965, and Global Production, Merck KGaA, Frankfurter Strausse 250D...

Publisher

American Chemical Society (ACS)

Subject

General Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/cc9000407

Reference37 articles.

1. Changing Requirements of Purification as Drug Discovery Programs Evolve from Hit Discovery

2. Developments of a Fully Automated Parallel HPLC/Mass Spectrometry System for the Analytical Characterization and Preparative Purification of Combinatorial Libraries

3. Automated analytical/preparative high-performance liquid chromatography–mass spectrometry system for the rapid characterization and purification of compound libraries

4. Structure-controlled automated purification of parallel synthesis products in drug discovery

5. High-Throughput Mass-Directed Parallel Purification Incorporating a Multiplexed Single Quadrupole Mass Spectrometer

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