Synthesis and Biological Evaluation of 2,4-Diamino-6-(arylaminomethyl)pyrido[2,3-d]pyrimidines as Inhibitors of Pneumocystis carinii and Toxoplasma gondii Dihydrofolate Reductase and as Antiopportunistic Infection and Antitumor Agents-Reference-Cited by-同舟云学术

Synthesis and Biological Evaluation of 2,4-Diamino-6-(arylaminomethyl)pyrido[2,3-d]pyrimidines as Inhibitors of Pneumocystis carinii and Toxoplasma gondii Dihydrofolate Reductase and as Antiopportunistic Infection and Antitumor Agents

Published:2003-10-04 Issue:23 Volume:46 Page:5074-5082
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Gangjee Aleem¹,Adair Ona O.¹,Queener Sherry F.¹

Affiliation:

1. Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, Pennsylvania 15282, and Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana 46202

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm030312n

Reference39 articles.

1. Drug Treatment of HIV-Related Opportunistic Infections

2. Infection prophylaxis and antiretroviral therapy in patients with HIV infection and malignancy

3. Activity of antifolates against Pneumocystis carinii dihydrofolate reductase and identification of a potent new agent.

4. Activity of lipid-soluble inhibitors of dihydrofolate reductase against Pneumocystis carinii in culture and in a rat model of infection

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